Dementia is a generic term used to describe a set of symptoms, including memory loss and changes to behaviour, as the result of progressive and irreversible neurodegenerative diseases.

Alzheimer’s disease is the most common cause of dementia, characterized by senile plaques, neurofibrillary tangles and neuroinflammation. Plaques form within the brain when amyloid precursor proteins are cleaved, and Aβ (amyloid beta) peptide accumulates outside nerve cells. Tangles occur inside nerve cells, when tau protein is hyperphosphorylated, forming abnormal paired strands, thereby destroying a vital cell transport system. Neuroinflammation mediated by glial cells, has been identified as a component in the neurodegeneration caused by Alzheimer’s disease. However, further research is still needed to fully understand the inflammatory processes.

Please view our Alzheimer’s disease products below, and please find our Alzheimer's disease flyer here.

EB08117 (5ug/ml) staining of paraffin embedded Rat Cerebral Cortex (A) and Rat Hippocampus (B), CRY-staining with DAPI nuclear counter stain in blue. Antigen retrieval with citrate buffer pH 6 at 95-98C.	EB09800 (2µg/ml) staining of paraffin embedded Human Cerebellum. Microwaved antigen retrieval with citrate buffer pH 6, HRP-staining.	EB09800 Negative Control showing staining of paraffin embedded Human Cerebellum, with no primary antibody.