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DNA repair

DNA is continuously prone to damage either by metabolism, or by environmental factors. Both nuclear and mitochondrial DNA can be affected. To maintain cellular integrity, the DNA repair machinery is constantly active as it responds to damage in the DNA structure. When this mechanism fails the cell could become senescent, it could enter apoptosis, or it could become cancerous.

The PARP family members are essential in a number of cellular functions. One important function of PARP is assisting in the repair of single-strand DNA nicks. PARP binds sites with single strand breaks through its N-terminal zinc fingers and will recruit XRCC1, DNA ligase III, DNA polymerase beta and a kinase to the nick. This process is called base excision repair (BER). BRCA repairs double strand breaks, but when BRCA is impaired, PARP can take over.

PARP inhibitors are currently being investigated as agents for chemotherapy, particularly for breast cancer.

Everest Biotech continues to expand its catalogue with antibodies to proteins involving DNA repair.
Please view the DNA repair products below, search our website or view our custom antibody and polyclonal antibody production services.

Antibodies for DNA repair

Everest code Principal name Applications Tested Species reactivity Size available
EB05345 Goat Anti-APE1 / APEX1 Antibody Pep-ELISA, WB, IHC Human, Dog, Pig, Cow 100µg/200µl
EB08162 Goat Anti-ASF1A Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog 100µg/200µl
EB07788 Goat Anti-ASF1A / HSPC146 Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog 100µg/200µl
EB07014 Goat Anti-BMYB / MYBL2 Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog, Pig, Cow 100µg/200µl
EB07232 Goat Anti-Casein Kinase 1, delta Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog 100µg/200µl
EB07758 Goat Anti-CSNK1E Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog 100µg/200µl
EB05033 Goat Anti-DDB1 Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog, Cow. This batch is not expected to cross-react with Rat in Western blot. 100µg/200µl
EB08190 Goat Anti-ERCC1 Antibody Pep-ELISA, WB Human 100µg/200µl
EB06113 Goat Anti-FANCG / XRCC9 Antibody Pep-ELISA, WB, IHC Human 100µg/200µl
EB05765 Goat Anti-HSPC150 / UBE2T Antibody Pep-ELISA, WB Human 100µg/200µl
EB05452 Goat Anti-ING2 / ING1L Antibody Pep-ELISA, WB Human, Cow 100µg/200µl
EB05473 Goat Anti-KLF4 / GKLF Antibody Pep-ELISA, WB Human, Mouse, Rat, Cow 100µg/200µl
EB07209 Goat Anti-Ku80 / XRCC5 Antibody Pep-ELISA, WB, IHC Human 100µg/200µl
EB05530 Goat Anti-MLH3 Antibody Pep-ELISA Human, Dog, Pig 100µg/200µl
EB06330 Goat Anti-MPG Antibody Pep-ELISA, WB Human 100µg/200µl
EB06329 Goat Anti-MUTYH Antibody Pep-ELISA, WB Human 100µg/200µl
EB05859 Goat Anti-NEIL1 / NEH1 Antibody Pep-ELISA, IHC Human, Pig, Cow 100µg/200µl
EB06986 Goat Anti-NEK9 Antibody Pep-ELISA Human, Mouse, Rat, Dog, Cow 100µg/200µl
EB05061 Goat Anti-P27KIP1 / CDKN1B (C Terminus) Antibody Pep-ELISA, WB, IP Human, Mouse, Rat, Cow, Dog 100µg/200µl
EB07131 Goat Anti-P27KIP1 / CDKN1B (internal) Antibody Pep-ELISA, WB, IHC Human, Mouse, Rat, Cat, Dog, Pig, Cow 100µg/200µl
EB07110 Goat Anti-PARP12 Antibody Pep-ELISA, IF Human, Dog 100µg/200µl
EB07098 Goat Anti-PARP2 Antibody Pep-ELISA, WB, IHC Human 100µg/200µl
EB09029 Goat Anti-PARP3 Antibody Pep-ELISA Human 100µg/200µl
EB07100 Goat Anti-PARP4 / VPARP Antibody ELISA Human, Mouse, Rat, Dog 100µg/200µl
EB05691 Goat Anti-PIR51 / RAD51AP1 Antibody Pep-ELISA, IHC Human, Dog, Cow 100µg/200µl
EB05539 Goat Anti-PMS1 Antibody Pep-ELISA Human 100µg/200µl
EB05517 Goat Anti-PNKP / PNK Antibody Pep-ELISA, WB Human 100µg/200µl
EB06206 Goat Anti-POLL / POLkappa Antibody Pep-ELISA, WB Human 100µg/200µl
EB06717 Goat Anti-PP2A / PPP2R1A Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog, Pig, Cow 100µg/200µl
EB06530 Goat Anti-PRDM4 / PFM1 Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog, Pig, Cow 100µg/200µl
EB05686 Goat Anti-RAD51C Antibody Pep-ELISA, WB Human 100µg/200µl
EB05692 Goat Anti-RAD51D / RAD51L3 Antibody Pep-ELISA Human 100µg/200µl
EB05687 Goat Anti-RAD51L1 Antibody Pep-ELISA Human, Pig, Cow 100µg/200µl
EB07550 Goat Anti-RAD9A Antibody Pep-ELISA, WB, EIA Human, Mouse, Dog 100µg/200µl
EB05989 Goat Anti-REV1L Antibody Pep-ELISA, IHC Human, Mouse, Rat, Dog, Cow 100µg/200µl
EB06542 Goat Anti-RIF1 (aa 2076-2089) Antibody Pep-ELISA, IHC Human 100µg/200µl
EB08932 Goat Anti-SEPT6 Antibody Pep-ELISA, WB, IHC Human, Cow, Dog 100µg/200µl
EB06321 Goat Anti-SMUG1 Antibody Pep-ELISA, WB, IHC Human 100µg/200µl
EB06358 Goat Anti-SNM1 (C Term) Antibody Pep-ELISA, IHC Human 100µg/200µl
EB07042 Goat Anti-SNM1 / DCLRE1A (internal) Antibody Pep-ELISA, IHC Human 100µg/200µl
EB08131 Goat Anti-TREX2 Antibody Pep-ELISA, IHC Human 100µg/200µl
EB07440 Goat Anti-XRCC4-like factor / NHEJ1 Antibody Pep-ELISA, WB, IHC Human, Dog 100µg/200µl