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Ubiquitin ligases

Ubiquitin ligases are part of a crucial regulatory mechanism dedicated to degrade and remove misfolded and denatured proteins by linking a chain of ubiquitin peptides to the targeted protein. The process involves Enzyme 1 (E1) that activates ubiquitin by forming a thioester bond, an ubiquitin conjugation enzyme (E2) that binds to the activated ubiquitin, and an ubiquitin ligase (E3) to link the ubiquitin to the targeted protein. This process goes through several cycles where the next ubiquitin is linked to the former until the polyubiquinated protein is recognized by the proteosome. A particular cell usually contains only a few types of E1 molecule, a greater diversity of E2s, and a very large variety of E3s.
In general, polyubiquitination leads to protein degradation in proteasomes, while monoubiquitination is a signal for protein endocytosis leading to lysosomal degradation.
Polyubiquination usually involves Lys48 in the ubiquitin peptide. This ubiquitinated lysine is recognized by the proteasome. However, Lys63 can also be used, and chains using this lysine are important for DNA repair, amongst other functions.
Mutations in ubiquitin ligases can cause genetic disorders, such as Fanconi anemia, Angelman-, Von Hippel-Lindau-, Liddle’s and 3-M syndrome.

Please view the ubiquitin ligases (including E3 ubiquitin ligases) below, search our website or view our custom antibody and polyclonal antibody production services.
 

Antibodies for Ubiquitin ligases

Everest code Principal name Applications Tested Species reactivity Size available
EB05813 Goat Anti-ARIH2 / TRIAD1 Antibody Pep-ELISA, WB, IF, IP Human, Mouse, Rat, Dog, Cow 100µg/200µl
EB05288 Goat Anti-CBL Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog, Pig, Cow 100µg/200µl
EB05819 Goat Anti-CHFR Antibody Pep-ELISA, IHC Human, Mouse, Rat, Pig Cow 100µg/200µl
EB09705 Goat Anti-DTX2 / Deltext-2 Antibody Pep-ELISA Human, Rat, Cow 100µg/200µl
EB05758 Goat Anti-E2-EPF / UBE2S Antibody Pep-ELISA Human, Mouse, Rat, Dog, Cow 100µg/200µl
EB05920 Goat Anti-EDD1 / HYD Antibody Pep-ELISA, IHC Human, Mouse, Rat, Pig, Cow 100µg/200µl
EB06061 Goat Anti-EMI2 Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog, Pig, Cow. This batch is not expected to cross-react with Human, Rat and Pig Testis, and Human Ovary in Western blot. 100µg/200µl
EB06473 Goat Anti-EndoNEDD4 / NEDL2 Antibody Pep-ELISA Human, Mouse, Rat, Cow 100µg/200µl
EB06041 Goat Anti-FBL2 / FBXL2 Antibody Pep-ELISA, WB, IHC Human, Rat, Dog, Cow 100µg/200µl
EB06050 Goat Anti-FBXL12 Antibody Pep-ELISA, IHC Human, Mouse, Rat, Dog 100µg/200µl
EB07392 Goat Anti-FBXL3 Antibody Pep-ELISA, WB, IHC Human, Mouse, Rat, Dog, Pig 100µg/200µl
EB06046 Goat Anti-FBXL6 Antibody Pep-ELISA Human, Mouse 100µg/200µl
EB09088 Goat Anti-FBXO32 Antibody Pep-ELISA, WB Human, Mouse, Rat, Cow, Pig 100µg/200µl
EB06059 Goat Anti-FBXO6 Antibody Pep-ELISA Human 100µg/200µl
EB05750 Goat Anti-HIP2 Antibody Pep-ELISA, WB, IHC Human, Mouse, Dog, Pig, Cow 100µg/200µl
EB05765 Goat Anti-HSPC150 / UBE2T Antibody Pep-ELISA, WB Human 100µg/200µl
EB09608 Goat Anti-HUWE1 / LASU1 Antibody Pep-ELISA Human, Mouse 100µg/200µl
EB07645 Goat Anti-ITCH / AIF4 Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog 100µg/200µl
EB05950 Goat Anti-KF1 / ZFP103 Antibody Pep-ELISA Human, Dog 100µg/200µl
EB06212 Goat Anti-LMO7 / FBXO20 Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog 100µg/200µl
EB07794 Goat Anti-LNX1 Antibody Pep-ELISA Human 100µg/200µl
EB06756 Goat Anti-Makorin Antibody Pep-ELISA, WB Human, Dog 100µg/200µl
EB08235 Goat Anti-MARCH10 Antibody Pep-ELISA, WB, IHC Human, Rat, Cow 100µg/200µl
EB08156 Goat Anti-MARCH2 / MARCH-II Antibody Pep-ELISA Human 100µg/200µl
EB08304 Goat Anti-MARCH-I Antibody Pep-ELISA Human, Mouse, Rat 100µg/200µl
EB08303 Goat Anti-MARCH-IV Antibody Pep-ELISA Human 100µg/200µl
EB08302 Goat Anti-MARCH-VII / Axotrophin Antibody Pep-ELISA, IHC Human, Mouse, Rat 100µg/200µl
EB06990 Goat Anti-MDM2 (isoform) Antibody Pep-ELISA, WB Human, Rat, Cat, Dog, Pig, Cow 100µg/200µl
EB07039 Goat Anti-MURF1 / TRIM63 (internal) Antibody Pep-ELISA, IHC Human, Mouse, Rat, Dog, Cow 100µg/200µl
EB05879 Goat Anti-MURF1 / TRIM63 (N Term) Antibody Pep-ELISA, IHC Human, Dog, Cow 100µg/200µl
EB07439 Goat Anti-PARK2 Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog 100µg/200µl
EB05880 Goat Anti-PARK7 / DJ-1 Antibody Pep-ELISA, WB, IF Human, Mouse, Rat 100µg/200µl
EB05929 Goat Anti-PJA1 Antibody Pep-ELISA Human 100µg/200µl
EB07140 Goat Anti-Rabring 7 / BCA2 Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog 100µg/200µl
EB05834 Goat Anti-RNF2 / dinG Antibody Pep-ELISA, WB Human, Mouse, Dog, Cow 100µg/200µl
EB05587 Goat Anti-RNF31 / ZIBRA (C terminus) Antibody Pep-ELISA, WB Human, Dog, Pig 100µg/200µl
EB05884 Goat Anti-RNF31 / ZIBRA (N terminus) Antibody Pep-ELISA Human 100µg/200µl
EB05842 Goat Anti-RNF7 / SAG / ROC2 Antibody Pep-ELISA Human, Mouse, Rat, Dog, Pig, Cow 100µg/200µl
EB05843 Goat Anti-RNF8 Antibody Pep-ELISA, WB Human 100µg/200µl
EB05292 Goat Anti-SIAH1 Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog, Cow 100µg/200µl
EB06975 Goat Anti-SMURF1 Antibody Pep-ELISA Human 100µg/200µl
EB05901 Goat Anti-SSA1 / Ro52 Antibody Pep-ELISA, WB-Trf Human 100µg/200µl
EB05327 Goat Anti-STUB1 / CHIP Antibody Pep-ELISA, WB Human, Mouse, Rat, Dog, Cow 100µg/200µl
EB08294 Goat Anti-TEB4 / MARCH-VI (aa 701 to 712) Antibody Pep-ELISA, WB Human, Mouse 100µg/200µl
EB08158 Goat Anti-TEB4 / MARCH-VI (aa 886 to 898) Antibody Pep-ELISA Human, Mouse 100µg/200µl
EB06379 Goat Anti-TRAC-1 / RNF125 Antibody Pep-ELISA Human, Mouse, Rat, Dog, Pig, Cow 100µg/200µl
EB05902 Goat Anti-TRC8 Antibody Pep-ELISA, WB, IHC Human, Dog 100µg/200µl
EB05908 Goat Anti-TRIM11 Antibody Pep-ELISA, IHC Human 100µg/200µl
EB05914 Goat Anti-TRIM2 Antibody Pep-ELISA, WB, IHC, IP Human, Mouse, Rat, Dog, Cow 100µg/200µl
EB05930 Goat Anti-TRIM36 / RNF98 Antibody Pep-ELISA, WB Human, Mouse, Rat 100µg/200µl
EB07084 Goat Anti-TRIM5 / RNF88 (alpha isoform) Antibody Pep-ELISA, IHC Human 100µg/200µl
EB05932 Goat Anti-TRIM5 / RNF88 Antibody Pep-ELISA, WB Human 100µg/200µl
EB09658 Goat Anti-UBR2 Antibody Pep-ELISA, IHC Human, Mouse, Dog, Cow 100µg/200µl
EB09611 Goat Anti-UBR4 / ZUBR1 Antibody Pep-ELISA, IHC Human, Mouse, Rat, Dog, Cow 100µg/200µl
EB07333 Goat Anti-VHL Antibody Pep-ELISA, WB, EIA Human, Mouse, Rat, Dog 100µg/200µl