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Goat Anti-KCNQ1 Antibody (EB09214)
| Code | Name | Applications | Availability | Size | Species reactivity | Price | Grade | |
|---|---|---|---|---|---|---|---|---|
| EB09214 | Goat Anti-KCNQ1 Antibody | Pep-ELISA, WB |  |
100µg specific antibody in 200µl | Human, Mouse, Rat, Dog, Cow | $315.00 |  |
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Ordering Information forOrder direct from Everest
$40.00: Overnight shipping to United States of America
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In stock orders received by 13.30 PST on Monday through Thursday are shipped the same day. Orders are placed with and invoiced by our US partner Abcore LLC.
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Target Protein
Principal Names: slow delayed rectifier channel subunit, long (electrocardiographic) QT syndrome, Ward-Romano syndrome 1, kidney and cardiac voltage dependend K+ channel, Jervell and Lange-Nielsen syndrome 1, WRS, SQT2, RWS, LQT1, LQT, Kv7.1, Kv1.9, KVLQT1, KCNA9, KCNA8, JLNS1, FLJ26167, ATFB1, potassium voltage-gated channel, KQT-like subfamily, member 1, KCNQ1Official Symbol: KCNQ1
Accession Number(s): NP_000209.2; NP_861463.1
Human GeneID(s): 3784
Non-Human GeneID(s): 16535 (mouse), 84020 (rat)
Important Comments: This antibody is expected to recognize both reported isoforms (NP_000209.2; NP_861463.1).
Immunogen
Peptide with sequence C-EQLTVPRRGPDEGS, from the C Terminus of the protein sequence according to NP_000209.2; NP_861463.1.
Please note the peptide is available for sale.
Purification and Storage
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Supplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin.
Aliquot and store at -20°C. Minimize freezing and thawing.
Applications Tested
Peptide ELISA: antibody detection limit dilution 1:16000.Western blot: Approx. 60kDa band observed in Human Heart lysates (calculated MW of 61.5kDa according to NP_861463.1). Recommended concentration: 1-3µg/ml. An additional band of unknown identity was also consistently observed at 28kDa. This band was successfully blocked by incubation with the immunizing peptide. We would appreciate any feedback from people in the field - have any such results been reported with other antibodies/lysates? Have any further splice variants/modified forms been reported?
Species Reactivity
Tested: HumanExpected from sequence similarity: Human, Mouse, Rat, Dog, Cow
Background Reference
Yasuda K, Miyake K, Horikawa Y, Hara K, Osawa H, Furuta H, Hirota Y, Mori H, Jonsson A, Sato Y, Yamagata K, Hinokio Y, Wang HY, Tanahashi T, Nakamura N, Oka Y, Iwasaki N, Iwamoto Y, Yamada Y, Seino Y, Maegawa H, Kashiwagi A, Takeda J, Maeda E, Shin HD, Cho YM, Park KS, Lee HK, Ng MC, Ma RC, So WY, Chan JC, Lyssenko V, Tuomi T, Nilsson P, Groop L, Kamatani N, Sekine A, Nakamura Y, Yamamoto K, Yoshida T, Tokunaga K, Itakura M, Makino H, Nanjo K, Kadowaki T, Kasuga M.
Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus.
Nat Genet. 2008 Aug 17. [Epub ahead of print].
PMID: 18711367