Since 2000, Everest Biotech has been designing a catalogue containing thousands of goat antibodies against a broad range of human, mouse and rat proteins of biomedical interest.
Everest Biotech’s commitment to quality and continuous improvement has been recognised with ISO 9001:2015 accreditation. Everest Biotech customers can be assured they will receive high quality products and excellent customer service.

The Allograft inflammatory factor 1 (AIF1/ Iba1) gene (GeneID: 199) is induced by cytokines including interferon-gamma (IFN-gamma). Its protein product contains 2 EF-hand motifs which bind Ca2+-ions, thus inducing a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. This protein product also binds actin; enhancing membrane ruffling and RAC activation via the phospholipase C-gamma -dependent pathway.

AIF1 is expressed in monocytes and macrophages, and is involved in macrophage activation and phagocytosis in activated microglia. It promotes the proliferation of T-lymphocytes, enhances lymphocyte migration and plays a role in both vascular inflammation and RAC signalling. It also promotes the growth of vascular smooth muscle cells (VSMC), by activation of Rac1 and induction of Granulocyte-Colony Stimulating Factor (G-CSF) expression.

Three transcript variants encoding different isoforms have been found for this gene. Both our EB05419 and EB07257 antibodies recognizes isoform 1 (NP_116573.1: 10.5kDa) and isoform 3 (NP_001614.3: 16.7kDa).

 Please see our AIF1/Iba1 antibodies below and the flyer here: